CREB1 and Smad3 mediate TGF-β3-induced Smad7 expression in rat hepatic stellate cells
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چکیده
منابع مشابه
Smad3 and PKC mediate TGF- 1-induced collagen I expression in human mesangial cells
Runyan, Constance E., H. William Schnaper, and Anne-Christine Poncelet. Smad3 and PKC mediate TGF1-induced collagen I expression in human mesangial cells. Am J Physiol Renal Physiol 285: F413–F422, 2003. First published May 20, 2003; 10.1152/ajprenal.00082.2003.— Transforming growth factor (TGF)has been associated with fibrogenesis in clinical studies and animal models. We previously showed tha...
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BACKGROUND/AIMS Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. METHODS Here, liver fibrosis was assessed subsequent to bile duct ligation by determining liver enzymes in serum and c...
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Background: The multifunctional transforming growth factor beta (TGF-β) is a glycoprotein that exists in three isoforms. TGF-β3 expression increases in fetal wound healing and reduces fibronectin and collagen I and III deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. Fibroblasts are key ...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.7654